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ey0017.11-6 | Body Weight and Appetite/Energy Regulation | ESPEYB17

11.6. Leptin’s hunger-suppressing effects are mediated by the hypothalamic-pituitary-adrenocortical axis in rodents

RJ Perry , JM Resch , AM Douglass , JC Madara , A Rabin-Court , H Kucukdereli , C Wu , JD Song , BB Lowell , GI Shulman

To read the full abstract: Proc Natl Acad Sci U S A 2019;116(27):1367013679. doi: https://pubmed.ncbi.nlm.nih.gov/31213533/In this paper, Perry et al. studied several animal models to disentangle the mechanism by which leptin suppresses hunger. In rats, the hyperphagia induced by a 48 h fast, or a hypoglycemic hyperinsulinemic clamp, or uncontrolled diabetes, was completely s...

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ey0017.11-7 | Body Weight and Appetite/Energy Regulation | ESPEYB17

11.7. Leptin mediates postprandial increases in body temperature through hypothalamus-adrenal medulla-adipose tissue crosstalk

RJ Perry , K Lyu , A Rabin-Court , J Dong , X Li , Y Yang , H Qing , A Wang , X Yang , GI Shulman

To read the full abstract: J Clin Invest 2020;130(4):200116.In this study, Perry et al used their well-established animal model of fasted rats to unravel how feeding induces hyperthermia and energy expenditure.They showed that intracerebroventricular injection of leptin normalized fasting induced low plasma epinephrine and norepinephrine levels and body temperat...

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ESPE Yearbook of Paediatric Endocrinology

11.6. Leptin’s hunger-suppressing effects are mediated by the hypothalamic-pituitary-adrenocortical axis in rodents

11.7. Leptin mediates postprandial increases in body temperature through hypothalamus-adrenal medulla-adipose tissue crosstalk

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